Modulation of microfilament by hepatotoxic cyclic peptide, cyclochlorotin
نویسندگان
چکیده
منابع مشابه
Biophysical properties and microfilament assembly in neutrophils: modulation by cyclic AMP
The microfilament lattice, composed primarily of filamentous (F)-actin, determines in large part the mechanical (deformability) properties of neutrophils, and thus may regulate the ability of neutrophils to transit a microvascular bed. Circulating factors may stimulate the neutrophil to become rigid and therefore be retained in the capillaries. We hypothesized that cell stiffening might be atte...
متن کاملGonadotropin-Releasing Response to Kisspeptin-10 and Its Modulation by Progesterone in Postpartum Cyclic Cows
The present study aimed to evaluate the effect of kisspeptin-10 (Kp10), a shorter variant of kisspeptin retaining full biological activity, on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in cyclic adult cows, and the effect of plasma progesterone (P4)concentration on the response to Kp10 administration. The experiments were performed using five postpartum cows...
متن کاملCyclic AMP, the microtubule-microfilament system, and cancer.
Additional evidence is presented for the previously proposed existence in normal fibroblasts of a cyclic AMP-dependent network of microtubules and microfilaments, which is connected with cell membrane elements on one end and with nuclear structures on the other and whose disorganization leads to malignant transformation. In the presence of cyclic AMP derivatives sufficient to promote integrity ...
متن کاملModulation of CD44 Activity by A6-Peptide
Hyaluronan (HA) is a non-sulfated glycosaminoglycan distributed throughout the extracellular matrix that plays a major role in cell adhesion, migration, and proliferation. CD44, a multifunctional cell surface glycoprotein, is a receptor for HA. In addition, CD44 is known to interact with other receptors and ligands, and to mediate a number of cellular functions as well as disease progression. S...
متن کاملProduction of the hepatotoxic chlorine-containing peptide by Penicillium islandicum Sopp.
Twenty-six strains of Penicillium islandicum Sopp were tested for production of a chlorine-containing peptide (Cl-peptide), which is a hepatotoxin. Highest levels of the mycotoxin were produced in a modification of Wickerham medium. The mycotoxin was isolated by adsorption on charcoal and, after washing the charcoal with acetone-water (1:1), was eluted into n-butanol. Further purification was a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mycotoxins
سال: 2000
ISSN: 0285-1466,1881-0128
DOI: 10.2520/myco1975.50.37